Cargando…

Fortification of yogurts with vitamin D and calcium enhances the inhibition of serum parathyroid hormone and bone resorption markers: A double blind randomized controlled trial in women over 60 living in a community dwelling home

OBJECTIVE: To evaluate whether fortification of yogurts with vitamin D and calcium exerts an additional lowering effect on serum parathyroid hormone (PTH) and bone resorption markers (BRM) as compared to iso-caloric and iso-protein dairy products in aged white women at risk of fragility fractures. D...

Descripción completa

Detalles Bibliográficos
Autores principales: Bonjour, Jean-Philippe, Benoit, V., Atkin, S., Walrand, S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Paris 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4681750/
https://www.ncbi.nlm.nih.gov/pubmed/25923487
http://dx.doi.org/10.1007/s12603-015-0498-8
_version_ 1782405762836856832
author Bonjour, Jean-Philippe
Benoit, V.
Atkin, S.
Walrand, S.
author_facet Bonjour, Jean-Philippe
Benoit, V.
Atkin, S.
Walrand, S.
author_sort Bonjour, Jean-Philippe
collection PubMed
description OBJECTIVE: To evaluate whether fortification of yogurts with vitamin D and calcium exerts an additional lowering effect on serum parathyroid hormone (PTH) and bone resorption markers (BRM) as compared to iso-caloric and iso-protein dairy products in aged white women at risk of fragility fractures. DESIGN: A randomized double-blind controlled trial. SETTING: A community dwelling home. PARTICIPANTS: Forty-eight women over 60 years (mean age 73.4). INTERVENTION: Consumption during 84 days of two 125 g servings of either vitamin D and calcium-fortified yogurts (FY) at supplemental levels of 10 µg vitamin D3/d and 520 mg/d of calcium (total=800 mg/d), or non fortified control yogurts (CY) providing 280 mg/d of calcium. MEASUREMENTS: Serum changes from baseline (D0) to D28, D56 and D84 in 25OHD, PTH and in two BRM: Tartrate-resistant-acid-phosphatase-isoform-5b (TRAP5b) and carboxy-terminal-cross-linked-telopeptide of type-I-collagen (CTX). RESULTS: The 10 years risk of major and hip fractures were 13.1 and 5.0%, and 12.9 and 4.2 %, in FY and CY groups, respectively. From D0 to D84, serum 25OHD increased (mean±SE) from 34.3±2.4 to 56.3±2.4 nmol/L in FY (n=24) and from 35.0±2.5 to 41.3±3.0 nmol/L in CY (n=24), (P=0.00001). The corresponding changes in PTH were from 64.1±5.1 to 47.4±3.8 ng/L in FY and from 63.5±4.6 to 60.7±4.2 ng/L in CY (P=0.0011). After D84, TRAP5b was reduced significantly (P=0.0228) and CTX fell though not significantly (P=0.0773) in FY compared to CY. CONCLUSION: This trial in aged white women living in a community dwelling home at risk for osteoporotic fractures confirms that fortification of dairy products with vitamin D3 and calcium should provide a greater prevention of secondary hyperparathyroidism and accelerated bone resorption as compared to non-fortified equivalent foods.
format Online
Article
Text
id pubmed-4681750
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher Springer Paris
record_format MEDLINE/PubMed
spelling pubmed-46817502015-12-23 Fortification of yogurts with vitamin D and calcium enhances the inhibition of serum parathyroid hormone and bone resorption markers: A double blind randomized controlled trial in women over 60 living in a community dwelling home Bonjour, Jean-Philippe Benoit, V. Atkin, S. Walrand, S. J Nutr Health Aging Article OBJECTIVE: To evaluate whether fortification of yogurts with vitamin D and calcium exerts an additional lowering effect on serum parathyroid hormone (PTH) and bone resorption markers (BRM) as compared to iso-caloric and iso-protein dairy products in aged white women at risk of fragility fractures. DESIGN: A randomized double-blind controlled trial. SETTING: A community dwelling home. PARTICIPANTS: Forty-eight women over 60 years (mean age 73.4). INTERVENTION: Consumption during 84 days of two 125 g servings of either vitamin D and calcium-fortified yogurts (FY) at supplemental levels of 10 µg vitamin D3/d and 520 mg/d of calcium (total=800 mg/d), or non fortified control yogurts (CY) providing 280 mg/d of calcium. MEASUREMENTS: Serum changes from baseline (D0) to D28, D56 and D84 in 25OHD, PTH and in two BRM: Tartrate-resistant-acid-phosphatase-isoform-5b (TRAP5b) and carboxy-terminal-cross-linked-telopeptide of type-I-collagen (CTX). RESULTS: The 10 years risk of major and hip fractures were 13.1 and 5.0%, and 12.9 and 4.2 %, in FY and CY groups, respectively. From D0 to D84, serum 25OHD increased (mean±SE) from 34.3±2.4 to 56.3±2.4 nmol/L in FY (n=24) and from 35.0±2.5 to 41.3±3.0 nmol/L in CY (n=24), (P=0.00001). The corresponding changes in PTH were from 64.1±5.1 to 47.4±3.8 ng/L in FY and from 63.5±4.6 to 60.7±4.2 ng/L in CY (P=0.0011). After D84, TRAP5b was reduced significantly (P=0.0228) and CTX fell though not significantly (P=0.0773) in FY compared to CY. CONCLUSION: This trial in aged white women living in a community dwelling home at risk for osteoporotic fractures confirms that fortification of dairy products with vitamin D3 and calcium should provide a greater prevention of secondary hyperparathyroidism and accelerated bone resorption as compared to non-fortified equivalent foods. Springer Paris 2015-12-17 2015 /pmc/articles/PMC4681750/ /pubmed/25923487 http://dx.doi.org/10.1007/s12603-015-0498-8 Text en © Serdi and Springer-Verlag France 2015
spellingShingle Article
Bonjour, Jean-Philippe
Benoit, V.
Atkin, S.
Walrand, S.
Fortification of yogurts with vitamin D and calcium enhances the inhibition of serum parathyroid hormone and bone resorption markers: A double blind randomized controlled trial in women over 60 living in a community dwelling home
title Fortification of yogurts with vitamin D and calcium enhances the inhibition of serum parathyroid hormone and bone resorption markers: A double blind randomized controlled trial in women over 60 living in a community dwelling home
title_full Fortification of yogurts with vitamin D and calcium enhances the inhibition of serum parathyroid hormone and bone resorption markers: A double blind randomized controlled trial in women over 60 living in a community dwelling home
title_fullStr Fortification of yogurts with vitamin D and calcium enhances the inhibition of serum parathyroid hormone and bone resorption markers: A double blind randomized controlled trial in women over 60 living in a community dwelling home
title_full_unstemmed Fortification of yogurts with vitamin D and calcium enhances the inhibition of serum parathyroid hormone and bone resorption markers: A double blind randomized controlled trial in women over 60 living in a community dwelling home
title_short Fortification of yogurts with vitamin D and calcium enhances the inhibition of serum parathyroid hormone and bone resorption markers: A double blind randomized controlled trial in women over 60 living in a community dwelling home
title_sort fortification of yogurts with vitamin d and calcium enhances the inhibition of serum parathyroid hormone and bone resorption markers: a double blind randomized controlled trial in women over 60 living in a community dwelling home
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4681750/
https://www.ncbi.nlm.nih.gov/pubmed/25923487
http://dx.doi.org/10.1007/s12603-015-0498-8
work_keys_str_mv AT bonjourjeanphilippe fortificationofyogurtswithvitamindandcalciumenhancestheinhibitionofserumparathyroidhormoneandboneresorptionmarkersadoubleblindrandomizedcontrolledtrialinwomenover60livinginacommunitydwellinghome
AT benoitv fortificationofyogurtswithvitamindandcalciumenhancestheinhibitionofserumparathyroidhormoneandboneresorptionmarkersadoubleblindrandomizedcontrolledtrialinwomenover60livinginacommunitydwellinghome
AT atkins fortificationofyogurtswithvitamindandcalciumenhancestheinhibitionofserumparathyroidhormoneandboneresorptionmarkersadoubleblindrandomizedcontrolledtrialinwomenover60livinginacommunitydwellinghome
AT walrands fortificationofyogurtswithvitamindandcalciumenhancestheinhibitionofserumparathyroidhormoneandboneresorptionmarkersadoubleblindrandomizedcontrolledtrialinwomenover60livinginacommunitydwellinghome