Leukotriene C(4) is the major trigger of stress-induced oxidative DNA damage

Endoplasmic reticulum (ER) stress and major chemotherapeutic agents damage DNA by generating reactive oxygen species (ROS). Here we show that ER stress and chemotherapy induce leukotriene C(4) (LTC(4)) biosynthesis by transcriptionally upregulating and activating the enzyme microsomal glutathione-S-...

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Detalles Bibliográficos
Autores principales: Dvash, Efrat, Har-Tal, Michal, Barak, Sara, Meir, Ofir, Rubinstein, Menachem
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4682057/
https://www.ncbi.nlm.nih.gov/pubmed/26656251
http://dx.doi.org/10.1038/ncomms10112

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4682057/
https://www.ncbi.nlm.nih.gov/pubmed/26656251
http://dx.doi.org/10.1038/ncomms10112

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