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Leukotriene C(4) is the major trigger of stress-induced oxidative DNA damage
Endoplasmic reticulum (ER) stress and major chemotherapeutic agents damage DNA by generating reactive oxygen species (ROS). Here we show that ER stress and chemotherapy induce leukotriene C(4) (LTC(4)) biosynthesis by transcriptionally upregulating and activating the enzyme microsomal glutathione-S-...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4682057/ https://www.ncbi.nlm.nih.gov/pubmed/26656251 http://dx.doi.org/10.1038/ncomms10112 |