A protein polymerization cascade mediates toxicity of non-pathological human huntingtin in yeast

Several neurodegenerative amyloidoses, including Huntington disease, are caused by expansion of polyglutamine (polyQ) stretches in otherwise unrelated proteins. In a yeast model, an N-terminal fragment of mutant huntingtin with a stretch of 103 glutamine residues aggregates and causes toxicity, whil...

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Detalles Bibliográficos
Autores principales: Serpionov, Genrikh V., Alexandrov, Alexander I., Antonenko, Yuri N., Ter-Avanesyan, Michael D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4682096/
https://www.ncbi.nlm.nih.gov/pubmed/26673834
http://dx.doi.org/10.1038/srep18407

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4682096/
https://www.ncbi.nlm.nih.gov/pubmed/26673834
http://dx.doi.org/10.1038/srep18407

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