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Controlling the Regional Identity of hPSC-Derived Neurons to Uncover Neuronal Subtype Specificity of Neurological Disease Phenotypes

The CNS contains many diverse neuronal subtypes, and most neurological diseases target specific subtypes. However, the mechanism of neuronal subtype specificity of disease phenotypes remains elusive. Although in vitro disease models employing human pluripotent stem cells (PSCs) have great potential...

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Detalles Bibliográficos
Autores principales: Imaizumi, Kent, Sone, Takefumi, Ibata, Keiji, Fujimori, Koki, Yuzaki, Michisuke, Akamatsu, Wado, Okano, Hideyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4682123/
https://www.ncbi.nlm.nih.gov/pubmed/26549851
http://dx.doi.org/10.1016/j.stemcr.2015.10.005