GC-elements controlling HRAS transcription form i-motif structures unfolded by heterogeneous ribonucleoprotein particle A1

HRAS is regulated by two neighbouring quadruplex-forming GC-elements (hras-1 and hras-2), located upstream of the major transcription start sites (doi: 10.1093/nar/gku 5784). In this study we demonstrate that the C-rich strands of hras-1 and hras-2 fold into i-motif conformations (iMs) characterized...

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Detalles Bibliográficos
Autores principales: Miglietta, Giulia, Cogoi, Susanna, Pedersen, Erik B., Xodo, Luigi E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4682182/
https://www.ncbi.nlm.nih.gov/pubmed/26674223
http://dx.doi.org/10.1038/srep18097

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4682182/
https://www.ncbi.nlm.nih.gov/pubmed/26674223
http://dx.doi.org/10.1038/srep18097

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