BPIQ, a novel synthetic quinoline derivative, inhibits growth and induces mitochondrial apoptosis of lung cancer cells in vitro and in zebrafish xenograft model

BACKGROUND: 2,9-Bis[2-(pyrrolidin-1-yl)ethoxy]-6-{4-[2-(pyrrolidin-1-yl)ethoxy] phenyl}-11H-indeno[1,2-c]quinolin-11-one (BPIQ) is a derivative from 6-arylindeno[1,2-c]quinoline. Our previous study showed the anti-cancer potential of BPIQ compared to its two analogues topotecan and irinotecan. In th...

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Detalles Bibliográficos
Autores principales: Chiu, Chien-Chih, Chou, Han-Lin, Chen, Bing-Hung, Chang, Kuo-Feng, Tseng, Chih-Hua, Fong, Yao, Fu, Tzu-Fun, Chang, Hsueh-Wei, Wu, Chang-Yi, Tsai, Eing-Mei, Lin, Shinne-Ren, Chen, Yeh-Long
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4682281/
https://www.ncbi.nlm.nih.gov/pubmed/26672745
http://dx.doi.org/10.1186/s12885-015-1970-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4682281/
https://www.ncbi.nlm.nih.gov/pubmed/26672745
http://dx.doi.org/10.1186/s12885-015-1970-x

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