Neurite Aggregation and Calcium Dysfunction in iPSC-Derived Sensory Neurons with Parkinson’s Disease-Related LRRK2 G2019S Mutation

Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most-common genetic determinants of Parkinson’s disease (PD). The G2019S mutation is detected most frequently and is associated with increased kinase activity. Whereas G2019S mutant dopamine neurons exhibit neurite elongation deficits, the ef...

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Detalles Bibliográficos
Autores principales: Schwab, Andrew J., Ebert, Allison D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4682343/
https://www.ncbi.nlm.nih.gov/pubmed/26651604
http://dx.doi.org/10.1016/j.stemcr.2015.11.004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4682343/
https://www.ncbi.nlm.nih.gov/pubmed/26651604
http://dx.doi.org/10.1016/j.stemcr.2015.11.004

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