Cargando…
An integrated bioinformatics analysis to dissect kinase dependency in triple negative breast cancer
BACKGROUND: Triple-Negative Breast Cancer (TNBC) is an aggressive disease with a poor prognosis. Clinically, TNBC patients have limited treatment options besides chemotherapy. The goal of this study was to determine the kinase dependency in TNBC cell lines and to predict compounds that could inhibit...
Autores principales: | Ryall, Karen A, Kim, Jihye, Klauck, Peter J, Shin, Jimin, Yoo, Minjae, Ionkina, Anastasia, Pitts, Todd M, Tentler, John J, Diamond, Jennifer R, Eckhardt, S Gail, Heasley, Lynn E, Kang, Jaewoo, Tan, Aik Choon |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4682411/ https://www.ncbi.nlm.nih.gov/pubmed/26681397 http://dx.doi.org/10.1186/1471-2164-16-S12-S2 |
Ejemplares similares
-
Efficacy and Molecular Mechanisms of Differentiated Response to the Aurora and Angiogenic Kinase Inhibitor ENMD-2076 in Preclinical Models of p53-Mutated Triple-Negative Breast Cancer
por: Ionkina, Anastasia A., et al.
Publicado: (2017) -
Systems Pharmacology-Based Approach of Connecting Disease Genes in Genome-Wide Association Studies with Traditional Chinese Medicine
por: Kim, Jihye, et al.
Publicado: (2018) -
K-Map: connecting kinases with therapeutics for drug repurposing and development
por: Kim, Jihye, et al.
Publicado: (2013) -
Antitumor activity of the polo-like kinase inhibitor, TAK-960, against preclinical models of colorectal cancer
por: Klauck, Peter J., et al.
Publicado: (2018) -
Antitumor activity of a potent MEK inhibitor, TAK-733, against colorectal cancer cell lines and patient derived xenografts
por: Lieu, Christopher H., et al.
Publicado: (2015)