Antibodies Are Required for Complete Vaccine-Induced Protection against Herpes Simplex Virus 2

Herpes simplex virus 2 (HSV-2) 0ΔNLS is a live HSV-2 ICP0 (-) mutant vaccine strain that is profoundly attenuated in vivo due to its interferon-hypersensitivity. Recipients of the HSV-2 0ΔNLS vaccine are resistant to high-dose HSV-2 challenge as evidenced by profound reductions in challenge virus sp...

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Detalles Bibliográficos
Autores principales: Halford, William P., Geltz, Joshua, Messer, Ronald J., Hasenkrug, Kim J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4682860/
https://www.ncbi.nlm.nih.gov/pubmed/26670699
http://dx.doi.org/10.1371/journal.pone.0145228

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4682860/
https://www.ncbi.nlm.nih.gov/pubmed/26670699
http://dx.doi.org/10.1371/journal.pone.0145228

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