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Antibodies Are Required for Complete Vaccine-Induced Protection against Herpes Simplex Virus 2
Herpes simplex virus 2 (HSV-2) 0ΔNLS is a live HSV-2 ICP0 (-) mutant vaccine strain that is profoundly attenuated in vivo due to its interferon-hypersensitivity. Recipients of the HSV-2 0ΔNLS vaccine are resistant to high-dose HSV-2 challenge as evidenced by profound reductions in challenge virus sp...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4682860/ https://www.ncbi.nlm.nih.gov/pubmed/26670699 http://dx.doi.org/10.1371/journal.pone.0145228 |