A Safe and Stable Neonatal Vaccine Targeting GAPDH Confers Protection against Group B Streptococcus Infections in Adult Susceptible Mice

Group B Streptococcus (GBS), a commensal organism, can turn into a life-threatening pathogen in neonates and elderly, or in adults with severe underlying diseases such as diabetes. We developed a vaccine targeting the GBS glyceraldehyde-3-phosphate dehydrogenase (GAPDH), a glycolytic enzyme detected...

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Detalles Bibliográficos
Autores principales: Alves, Joana, Madureira, Pedro, Baltazar, Maria Teresa, Barros, Leandro, Oliveira, Liliana, Dinis-Oliveira, Ricardo Jorge, Andrade, Elva Bonifácio, Ribeiro, Adília, Vieira, Luís Mira, Trieu-Cuot, Patrick, Duarte, José Alberto, Carvalho, Félix, Ferreira, Paula
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4682941/
https://www.ncbi.nlm.nih.gov/pubmed/26673420
http://dx.doi.org/10.1371/journal.pone.0144196

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4682941/
https://www.ncbi.nlm.nih.gov/pubmed/26673420
http://dx.doi.org/10.1371/journal.pone.0144196

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