Cargando…

A Safe and Stable Neonatal Vaccine Targeting GAPDH Confers Protection against Group B Streptococcus Infections in Adult Susceptible Mice

Group B Streptococcus (GBS), a commensal organism, can turn into a life-threatening pathogen in neonates and elderly, or in adults with severe underlying diseases such as diabetes. We developed a vaccine targeting the GBS glyceraldehyde-3-phosphate dehydrogenase (GAPDH), a glycolytic enzyme detected...

Descripción completa

Detalles Bibliográficos
Autores principales:	Alves, Joana, Madureira, Pedro, Baltazar, Maria Teresa, Barros, Leandro, Oliveira, Liliana, Dinis-Oliveira, Ricardo Jorge, Andrade, Elva Bonifácio, Ribeiro, Adília, Vieira, Luís Mira, Trieu-Cuot, Patrick, Duarte, José Alberto, Carvalho, Félix, Ferreira, Paula
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4682941/ https://www.ncbi.nlm.nih.gov/pubmed/26673420 http://dx.doi.org/10.1371/journal.pone.0144196

Ejemplares similares

Inhibition of IL-10 Production by Maternal Antibodies against Group B Streptococcus GAPDH Confers Immunity to Offspring by Favoring Neutrophil Recruitment
por: Madureira, Pedro, et al.
Publicado: (2011)

Group B Streptococcus GAPDH Is Released upon Cell Lysis, Associates with Bacterial Surface, and Induces Apoptosis in Murine Macrophages
por: Oliveira, Liliana, et al.
Publicado: (2012)

Group B Streptococcus Hijacks the Host Plasminogen System to Promote Brain Endothelial Cell Invasion
por: Magalhães, Vanessa, et al.
Publicado: (2013)

A mouse model reproducing the pathophysiology of neonatal group B streptococcal infection
por: Andrade, Elva Bonifácio, et al.
Publicado: (2018)

Streptococcus pneumoniae GAPDH Is Released by Cell Lysis and Interacts with Peptidoglycan
por: Terrasse, Rémi, et al.
Publicado: (2015)

SecA Localization and SecA-Dependent Secretion Occurs at New Division Septa in Group B Streptococcus
por: Brega, Sara, et al.
Publicado: (2013)

A Comparison Between Recombinant Listeria GAPDH Proteins and GAPDH Encoding mRNA Conjugated to Lipids as Cross-Reactive Vaccines for Listeria, Mycobacterium, and Streptococcus
por: Teran-Navarro, Hector, et al.
Publicado: (2021)

Evidence for the Sialylation of PilA, the PI-2a Pilus-Associated Adhesin of Streptococcus agalactiae Strain NEM316
por: Morello, Eric, et al.
Publicado: (2015)

Surface Export of GAPDH/SDH, a Glycolytic Enzyme, Is Essential for Streptococcus pyogenes Virulence
por: Jin, Hong, et al.
Publicado: (2011)

Subcutaneous Streptococcus dysgalactiae GAPDH vaccine in mice induces a proficient innate immune response
por: An, Ran, et al.
Publicado: (2023)

Dual Role for Pilus in Adherence to Epithelial Cells and Biofilm Formation in Streptococcus agalactiae
por: Konto-Ghiorghi, Yoan, et al.
Publicado: (2009)

Characterization of a Four-Component Regulatory System Controlling Bacteriocin Production in Streptococcus gallolyticus
por: Proutière, Alexis, et al.
Publicado: (2021)

Porphyromonas gingivalis HmuY and Streptococcus gordonii GAPDH—Novel Heme Acquisition Strategy in the Oral Microbiome
por: Ślęzak, Paulina, et al.
Publicado: (2020)

An in silico model for identification of small RNAs in whole bacterial genomes: characterization of antisense RNAs in pathogenic Escherichia coli and Streptococcus agalactiae strains
por: Pichon, Christophe, et al.
Publicado: (2012)

S-nitrosylation of B23/nucleophosmin by GAPDH protects cells from the SIAH1–GAPDH death cascade
por: Lee, Sang Bae, et al.
Publicado: (2012)

Cyclic di-AMP regulation of osmotic homeostasis is essential in Group B Streptococcus
por: Devaux, Laura, et al.
Publicado: (2018)

Streptococcus pneumoniae binds to host GAPDH on dying lung epithelial cells worsening secondary infection following influenza
por: Park, Sang-Sang, et al.
Publicado: (2021)

GAPDH Mediates Nitrosylation of Nuclear Proteins
por: Kornberg, Michael D., et al.
Publicado: (2010)

Malonylation of GAPDH is an inflammatory signal in macrophages
por: Galván-Peña, Silvia, et al.
Publicado: (2019)

Physiology, phylogeny, early evolution, and GAPDH
por: Martin, William F., et al.
Publicado: (2017)

GAPDH in neuroblastoma: Functions in metabolism and survival
por: Cornett, Kevin, et al.
Publicado: (2022)

Pseudogenes as Weaknesses of ACTB (Actb) and GAPDH (Gapdh) Used as Reference Genes in Reverse Transcription and Polymerase Chain Reactions
por: Sun, Yuan, et al.
Publicado: (2012)

Transcriptome profiling of human col\onic cells exposed to the gut pathobiont Streptococcus gallolyticus subsp. gallolyticus
por: Pasquereau-Kotula, Ewa, et al.
Publicado: (2023)

D-Alanylation of Lipoteichoic Acids Confers Resistance to Cationic Peptides in Group B Streptococcus by Increasing the Cell Wall Density
por: Saar-Dover, Ron, et al.
Publicado: (2012)

The Writers, Readers, and Erasers in Redox Regulation of GAPDH
por: Tossounian, Maria-Armineh, et al.
Publicado: (2020)

Role of the Group B Antigen of Streptococcus agalactiae: A Peptidoglycan-Anchored Polysaccharide Involved in Cell Wall Biogenesis
por: Caliot, Élise, et al.
Publicado: (2012)

Regulation of PI-2b Pilus Expression in Hypervirulent Streptococcus agalactiae ST-17 BM110
por: Périchon, Bruno, et al.
Publicado: (2017)

Correction: D-Alanylation of Lipoteichoic Acids Confers Resistance to Cationic Peptides in Group B Streptococcus by Increasing the Cell Wall Density
por: Saar-Dover, Ron, et al.
Publicado: (2012)

Detection of Streptococcus gallolyticus and Four Other CRC-Associated Bacteria in Patient Stools Reveals a Potential “Driver” Role for Enterotoxigenic Bacteroides fragilis
por: Périchon, Bruno, et al.
Publicado: (2022)

GAPDH is not regulated in human glioblastoma under hypoxic conditions
por: Said, Harun M, et al.
Publicado: (2007)

GAPDH Pseudogenes and the Quantification of Feline Genomic DNA Equivalents
por: Helfer-Hungerbuehler, A. Katrin, et al.
Publicado: (2013)

Cellular vaccines in listeriosis: role of the Listeria antigen GAPDH
por: Calderón-González, Ricardo, et al.
Publicado: (2014)

Structural Study of Monomethyl Fumarate-Bound Human GAPDH
por: Park, Jun Bae, et al.
Publicado: (2019)

Data highlighting miR-155 and GAPDH correlation
por: Khanna, Madhu, et al.
Publicado: (2019)

Origin of Elevated S-Glutathionylated GAPDH in Chronic Neurodegenerative Diseases
por: Hyslop, Paul A., et al.
Publicado: (2023)

The Abi-domain Protein Abx1 Interacts with the CovS Histidine Kinase to Control Virulence Gene Expression in Group B Streptococcus
por: Firon, Arnaud, et al.
Publicado: (2013)

The CovR regulatory network drives the evolution of Group B Streptococcus virulence
por: Mazzuoli, Maria-Vittoria, et al.
Publicado: (2021)

Identification of immunogenic proteins and evaluation of recombinant PDHA1 and GAPDH as potential vaccine candidates against Streptococcus iniae infection in flounder (Paralichthys olivaceus)
por: Sheng, Xiuzhen, et al.
Publicado: (2018)

The surface protein HvgA mediates group B streptococcus hypervirulence and meningeal tropism in neonates
por: Tazi, Asmaa, et al.
Publicado: (2010)

Ishemia-Reperfusion enhances GAPDH nitration in aging skeletal muscle
por: Bailey, C. Eric, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_1l8pic28h3r273gf35k992cg90