The Cytoprotective Effect of Hyperoside against Oxidative Stress Is Mediated by the Nrf2-ARE Signaling Pathway through GSK-3β Inactivation

Glycogen synthase kinase-3β (GSK-3β) acts as a negative regulator of NF-E2 related factor 2 (Nrf2) by inducing Nrf2 degradation and nuclear export. Our previous study demonstrated that the flavonoid hyperoside elicits cytoprotection against oxidative stress by activating the Keap1-Nrf2-ARE signaling...

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Detalles Bibliográficos
Autores principales: Xing, Hai-Yan, Cai, Yong-Qing, Wang, Xian-Feng, Wang, Lin-Li, Li, Pan, Wang, Guan-Ying, Chen, Jian-Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4682950/
https://www.ncbi.nlm.nih.gov/pubmed/26674355
http://dx.doi.org/10.1371/journal.pone.0145183

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4682950/
https://www.ncbi.nlm.nih.gov/pubmed/26674355
http://dx.doi.org/10.1371/journal.pone.0145183

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