Engineering of Immunoglobulin Fc Heterodimers Using Yeast Surface-Displayed Combinatorial Fc Library Screening

Immunoglobulin Fc heterodimers, which are useful scaffolds for the generation of bispecific antibodies, have been mostly generated through structure-based rational design methods that introduce asymmetric mutations into the CH3 homodimeric interface to favor heterodimeric Fc formation. Here, we repo...

Descripción completa

Detalles Bibliográficos
Autores principales: Choi, Hye-Ji, Kim, Ye-Jin, Choi, Dong-Ki, Kim, Yong-Sung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4682967/
https://www.ncbi.nlm.nih.gov/pubmed/26675656
http://dx.doi.org/10.1371/journal.pone.0145349

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4682967/
https://www.ncbi.nlm.nih.gov/pubmed/26675656
http://dx.doi.org/10.1371/journal.pone.0145349

Ejemplares similares