Cargando…

ShcA Protects against Epithelial–Mesenchymal Transition through Compartmentalized Inhibition of TGF-β-Induced Smad Activation

Epithelial–mesenchymal transition (EMT) is a normal cell differentiation event during development and contributes pathologically to carcinoma and fibrosis progression. EMT often associates with increased transforming growth factor-β (TGF-β) signaling, and TGF-β drives EMT, in part through Smad-media...

Descripción completa

Detalles Bibliográficos
Autores principales:	Muthusamy, Baby Periyanayaki, Budi, Erine H., Katsuno, Yoko, Lee, Matthew K., Smith, Susan M., Mirza, Amer M., Akhurst, Rosemary J., Derynck, Rik
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4682977/ https://www.ncbi.nlm.nih.gov/pubmed/26680585 http://dx.doi.org/10.1371/journal.pbio.1002325

Ejemplares similares

Enhanced TGF-β Signaling Contributes to the Insulin-Induced Angiogenic Responses of Endothelial Cells
por: Budi, Erine H., et al.
Publicado: (2019)

Integration of TGF-β-induced Smad signaling in the insulin-induced transcriptional response in endothelial cells
por: Budi, Erine H., et al.
Publicado: (2019)

p66ShcA functions as a contextual promoter of breast cancer metastasis
por: Lewis, Kyle, et al.
Publicado: (2020)

Ras, TrkB, and ShcA Protein Expression Patterns in Pediatric Brain Tumors
por: Prill, Monika, et al.
Publicado: (2021)

p66ShcA potentiates the cytotoxic response of triple-negative breast cancers to PARP inhibitors
por: Cañedo, Eduardo Cepeda, et al.
Publicado: (2021)

Roles of Autocrine TGF-β Receptor and Smad Signaling in Adipocyte Differentiation
por: Choy, Lisa, et al.
Publicado: (2000)

Loss of the adaptor protein ShcA in endothelial cells protects against monocyte macrophage adhesion, LDL-oxydation, and atherosclerotic lesion formation
por: Abou-Jaoude, Antoine, et al.
Publicado: (2018)

Genetic inactivation of mitochondria-targeted redox enzyme p66ShcA preserves neuronal viability and mitochondrial integrity in response to oxidative challenges
por: Su, Kimmy, et al.
Publicado: (2012)

Author Correction: Loss of the adaptor protein ShcA in endothelial cells protects against monocyte macrophage adhesion, LDL-oxydation, and atherosclerotic lesion formation
por: Abou-Jaoude, Antoine, et al.
Publicado: (2018)

Cell size and invasion in TGF-β–induced epithelial to mesenchymal transition is regulated by activation of the mTOR pathway
por: Lamouille, Samy, et al.
Publicado: (2007)

Does Smad6 methylation control BMP signaling in cancer?
por: Xu, Jian, et al.
Publicado: (2014)

Increased Level of Phosphorylated ShcA Measured by Chemiluminescence-Linked Immunoassay Is a Predictor of Good Prognosis in Primary Breast Cancer Expressing Low Levels of Estrogen Receptor
por: Cicenas, Jonas, et al.
Publicado: (2010)

Role of TGF-β in the motility of ShcD-overexpressing 293 cells
por: Amer, Sara, et al.
Publicado: (2019)

The Tetraspanin Cd9 Associates with Transmembrane TGF-α and Regulates TGF-α–Induced Egf Receptor Activation and Cell Proliferation
por: Shi, Wen, et al.
Publicado: (2000)

Complexities of TGF-β Targeted Cancer Therapy
por: Connolly, Erin C., et al.
Publicado: (2012)

TGFβ: Signaling Blockade for Cancer Immunotherapy
por: Chen, Szu-Ying, et al.
Publicado: (2022)

ATHEROSCLEROSIS NEEDS SHC
por: Robinson, Richard
Publicado: (2008)

TGF-β/SMAD signaling regulation of mesenchymal stem cells in adipocyte commitment
por: Li, Sheng-Nan, et al.
Publicado: (2020)

SUMOylation of Smad2 mediates TGF-β-regulated endothelial–mesenchymal transition
por: Su, Qi, et al.
Publicado: (2023)

CDCA7 promotes TGF‐β‐induced epithelial–mesenchymal transition via transcriptionally regulating Smad4/Smad7 in ESCC
por: Li, Hongyi, et al.
Publicado: (2022)

Localization of phosphotyrosine adaptor protein ShcD/SHC4 in the adult rat central nervous system
por: Robeson, Hannah N., et al.
Publicado: (2019)

Amygdalin Promotes Fracture Healing through TGF-β/Smad Signaling in Mesenchymal Stem Cells
por: Ying, Jun, et al.
Publicado: (2020)

The platinum coordination complex inhibits cell invasion-migration and epithelial-to-mesenchymal transition by altering the TGF-β-SMAD pathway in colorectal cancer
por: Abdulla, Maha-Hamadien, et al.
Publicado: (2023)

P66Shc signals to age
por: Trinei, Mirella, et al.
Publicado: (2009)

The neuronal Shc adaptor in Alzheimer’s Disease
por: Triaca, Viviana, et al.
Publicado: (2018)

Insights into the Shc Family of Adaptor Proteins
por: Ahmed, Samrein B. M., et al.
Publicado: (2017)

p66Shc in Cardiovascular Pathology
por: Haslem, Landon, et al.
Publicado: (2022)

Human SHC‐transforming protein 1 and its isoforms p66shc: A novel marker for prediabetes
por: Jelinek, Herbert F, et al.
Publicado: (2021)

Expression of a Truncated, Kinase-Defective TGF-β Type II Receptor in Mouse Skeletal Tissue Promotes Terminal Chondrocyte Differentiation and Osteoarthritis
por: Serra, Rosa, et al.
Publicado: (1997)

SMAD3 and SMAD4 have a more dominant role than SMAD2 in TGFβ-induced chondrogenic differentiation of bone marrow-derived mesenchymal stem cells
por: de Kroon, Laurie M. G., et al.
Publicado: (2017)

TGF-β/Smad signaling in renal fibrosis
por: Meng, Xiao-Ming, et al.
Publicado: (2015)

Loss of N-Myc interactor promotes epithelial-mesenchymal-transition by activation of TGF-β/SMAD signaling
por: Devine, Daniel J., et al.
Publicado: (2013)

Thalidomide Inhibits TGF-β1-induced Epithelial to Mesenchymal Transition in Alveolar Epithelial Cells via Smad-Dependent and Smad-Independent Signaling Pathways
por: Zhou, Xian-Long, et al.
Publicado: (2017)

Eps15R is required for bone morphogenetic protein signalling and differentially compartmentalizes with Smad proteins
por: Callery, Elizabeth M., et al.
Publicado: (2012)

Bone morphogenetic protein and retinoic acid signaling cooperate to induce osteoblast differentiation of preadipocytes
por: Skillington, Jeremy, et al.
Publicado: (2002)

TGF-Beta Induced Erk Phosphorylation of Smad Linker Region Regulates Smad Signaling
por: Hough, Chris, et al.
Publicado: (2012)

SMAD2/3 mediate oncogenic effects of TGF-β in the absence of SMAD4
por: Bertrand-Chapel, Adrien, et al.
Publicado: (2022)

Exogenous Heparan Sulfate Enhances the TGF-β3-Induced Chondrogenesis in Human Mesenchymal Stem Cells by Activating TGF-β/Smad Signaling
por: Chen, Juan, et al.
Publicado: (2016)

P66SHC and Ageing: ROS and TOR?
por: Pani, Giovambattista
Publicado: (2010)

P66Shc and vascular endothelial function
por: Kumar, Santosh
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_f6np67bkmb90h6kcf0rmvv37gv