Zinc enhancement of cytidine deaminase activity highlights a potential allosteric role of loop-3 in regulating APOBEC3 enzymes

The strong association of APOBEC3 cytidine deaminases with somatic mutations leading to cancers accentuates the importance of their tight intracellular regulation to minimize cellular transformations. We reveal a novel allosteric regulatory mechanism of APOBEC3 enzymes showing that APOBEC3G and APOB...

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Detalles Bibliográficos
Autores principales: Marx, Ailie, Galilee, Meytal, Alian, Akram
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4683357/
https://www.ncbi.nlm.nih.gov/pubmed/26678087
http://dx.doi.org/10.1038/srep18191

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4683357/
https://www.ncbi.nlm.nih.gov/pubmed/26678087
http://dx.doi.org/10.1038/srep18191

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