Breast cancer 1 (BRCA1)-deficient embryos develop normally but are more susceptible to ethanol-initiated DNA damage and embryopathies()

The breast cancer 1 (brca1) gene is associated with breast and ovarian cancers, and heterozygous (+/−) brca1 knockout progeny develop normally, suggesting a negligible developmental impact. However, our results show BRCA1 plays a broader biological role in protecting the embryo from oxidative stress...

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Detalles Bibliográficos
Autores principales: Shapiro, Aaron M., Miller-Pinsler, Lutfiya, Wells, Peter G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4683388/
https://www.ncbi.nlm.nih.gov/pubmed/26629949
http://dx.doi.org/10.1016/j.redox.2015.11.005

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4683388/
https://www.ncbi.nlm.nih.gov/pubmed/26629949
http://dx.doi.org/10.1016/j.redox.2015.11.005

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