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Using activation status of signaling pathways as mechanism-based biomarkers to predict drug sensitivity
Many complex traits, as drug response, are associated with changes in biological pathways rather than being caused by single gene alterations. Here, a predictive framework is presented in which gene expression data are recoded into activity statuses of signal transduction circuits (sub-pathways with...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4683444/ https://www.ncbi.nlm.nih.gov/pubmed/26678097 http://dx.doi.org/10.1038/srep18494 |