PRINT: A Protein Bioconjugation Method with Exquisite N-terminal Specificity

Chemical conjugation is commonly used to enhance the pharmacokinetics, biodistribution, and potency of protein therapeutics, but often leads to non-specific modification or loss of bioactivity. Here, we present a simple, versatile and widely applicable method that allows exquisite N-terminal specifi...

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Detalles Bibliográficos
Autores principales: Sur, Surojit, Qiao, Yuan, Fries, Anja, O’Meally, Robert N., Cole, Robert N., Kinzler, Kenneth W., Vogelstein, Bert, Zhou, Shibin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4683619/
https://www.ncbi.nlm.nih.gov/pubmed/26678960
http://dx.doi.org/10.1038/srep18363

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4683619/
https://www.ncbi.nlm.nih.gov/pubmed/26678960
http://dx.doi.org/10.1038/srep18363

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