Predicting target proteins for drug candidate compounds based on drug-induced gene expression data in a chemical structure-independent manner

BACKGROUND: Phenotype-based high-throughput screening is a useful technique for identifying drug candidate compounds that have a desired phenotype. However, the molecular mechanisms of the hit compounds remain unknown, and substantial effort is required to identify the target proteins associated wit...

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Detalles Bibliográficos
Autores principales: Hizukuri, Yoshiyuki, Sawada, Ryusuke, Yamanishi, Yoshihiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4683716/
https://www.ncbi.nlm.nih.gov/pubmed/26684652
http://dx.doi.org/10.1186/s12920-015-0158-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4683716/
https://www.ncbi.nlm.nih.gov/pubmed/26684652
http://dx.doi.org/10.1186/s12920-015-0158-1

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