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Predicting target proteins for drug candidate compounds based on drug-induced gene expression data in a chemical structure-independent manner
BACKGROUND: Phenotype-based high-throughput screening is a useful technique for identifying drug candidate compounds that have a desired phenotype. However, the molecular mechanisms of the hit compounds remain unknown, and substantial effort is required to identify the target proteins associated wit...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4683716/ https://www.ncbi.nlm.nih.gov/pubmed/26684652 http://dx.doi.org/10.1186/s12920-015-0158-1 |