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HIV-1 transcriptional silencing caused by TRIM22 inhibition of Sp1 binding to the viral promoter
BACKGROUND: Intracellular defense proteins, also referred to as restriction factors, are capable of interfering with different steps of the viral life cycle. Among these, we have shown that Tripartite motif 22 (TRIM22) suppresses basal as well as phorbol ester-induced HIV-1 long terminal repeat (LTR...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4683785/ https://www.ncbi.nlm.nih.gov/pubmed/26683615 http://dx.doi.org/10.1186/s12977-015-0230-0 |