Haematological profile of 21 patients with hairy cell leukaemia in a tertiary care centre of north India

BACKGROUND & OBJECTIVES: Hairy cell leukaemia (HCL) is a B cell neoplasm which constitutes around 2 per cent of all the lymphoid leukaemias. It has a characteristic morphology and immunophenotypic profile. It is important to distinguish HCL from other B cell lymphoproliferative disorders due to...

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Autores principales: Gupta, Arvind Kumar, Sachdeva, Man Updesh Singh, Ahluwalia, Jasmina, Das, Reena, Naseem, Shano, Sharma, Prashant, Kumar, Narender, Malhotra, Pankaj, Varma, Neelam, Varma, Subhash
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2015
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4683827/
https://www.ncbi.nlm.nih.gov/pubmed/26609034
http://dx.doi.org/10.4103/0971-5916.169204
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author Gupta, Arvind Kumar
Sachdeva, Man Updesh Singh
Ahluwalia, Jasmina
Das, Reena
Naseem, Shano
Sharma, Prashant
Kumar, Narender
Malhotra, Pankaj
Varma, Neelam
Varma, Subhash
author_facet Gupta, Arvind Kumar
Sachdeva, Man Updesh Singh
Ahluwalia, Jasmina
Das, Reena
Naseem, Shano
Sharma, Prashant
Kumar, Narender
Malhotra, Pankaj
Varma, Neelam
Varma, Subhash
author_sort Gupta, Arvind Kumar
collection PubMed
description BACKGROUND & OBJECTIVES: Hairy cell leukaemia (HCL) is a B cell neoplasm which constitutes around 2 per cent of all the lymphoid leukaemias. It has a characteristic morphology and immunophenotypic profile. It is important to distinguish HCL from other B cell lymphoproliferative disorders due to availability of different chemotherapeutic agents. This study presents clinical, haematological and immunophenotypic profile of patients with HCL seen over a period of four years in a tertiary care hospital in north India. METHODS: Twenty one cases of hairy cell leukaemia were analyzed for their clinical details, haemogram, bone marrow examination and immunophenotypic findings. RESULTS: Age of the patients ranged from 28-76 yr with male predominance. Weakness and fever were commonest presentations. Splenomegaly, hepatomegaly, lymphadenopathy were seen in decreasing order of frequency. Anaemia was noted in all 21 patients, leukopenia in 15 and thrombocytopenia in 19 cases. Fourteen patients were pancytopenic. Bone marrow examination showed typical hairy cells in all cases. Immunophenotyping showed expression of CD19, CD20, CD103, CD25 and CD11c in all cases, while positivity was seen for CD79b in 93.7 per cent, kappa light chain restriction in 60 per cent and lambda in 40 per cent cases. Notably, 20 per cent showed CD10 and 12 per cent showed CD23 expression. INTERPRETATION & CONCLUSIONS: This study reveals some unusual findings in otherwise classical disease entity, like absence of palpable spleen, presence of lymphadenopathy, normal or elevated leukocyte counts, expression of CD10, which at times could be diagnostically challenging.
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spelling pubmed-46838272015-12-28 Haematological profile of 21 patients with hairy cell leukaemia in a tertiary care centre of north India Gupta, Arvind Kumar Sachdeva, Man Updesh Singh Ahluwalia, Jasmina Das, Reena Naseem, Shano Sharma, Prashant Kumar, Narender Malhotra, Pankaj Varma, Neelam Varma, Subhash Indian J Med Res Original Article BACKGROUND & OBJECTIVES: Hairy cell leukaemia (HCL) is a B cell neoplasm which constitutes around 2 per cent of all the lymphoid leukaemias. It has a characteristic morphology and immunophenotypic profile. It is important to distinguish HCL from other B cell lymphoproliferative disorders due to availability of different chemotherapeutic agents. This study presents clinical, haematological and immunophenotypic profile of patients with HCL seen over a period of four years in a tertiary care hospital in north India. METHODS: Twenty one cases of hairy cell leukaemia were analyzed for their clinical details, haemogram, bone marrow examination and immunophenotypic findings. RESULTS: Age of the patients ranged from 28-76 yr with male predominance. Weakness and fever were commonest presentations. Splenomegaly, hepatomegaly, lymphadenopathy were seen in decreasing order of frequency. Anaemia was noted in all 21 patients, leukopenia in 15 and thrombocytopenia in 19 cases. Fourteen patients were pancytopenic. Bone marrow examination showed typical hairy cells in all cases. Immunophenotyping showed expression of CD19, CD20, CD103, CD25 and CD11c in all cases, while positivity was seen for CD79b in 93.7 per cent, kappa light chain restriction in 60 per cent and lambda in 40 per cent cases. Notably, 20 per cent showed CD10 and 12 per cent showed CD23 expression. INTERPRETATION & CONCLUSIONS: This study reveals some unusual findings in otherwise classical disease entity, like absence of palpable spleen, presence of lymphadenopathy, normal or elevated leukocyte counts, expression of CD10, which at times could be diagnostically challenging. Medknow Publications & Media Pvt Ltd 2015-10 /pmc/articles/PMC4683827/ /pubmed/26609034 http://dx.doi.org/10.4103/0971-5916.169204 Text en Copyright: © Indian Journal of Medical Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution NonCommercial ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Original Article
Gupta, Arvind Kumar
Sachdeva, Man Updesh Singh
Ahluwalia, Jasmina
Das, Reena
Naseem, Shano
Sharma, Prashant
Kumar, Narender
Malhotra, Pankaj
Varma, Neelam
Varma, Subhash
Haematological profile of 21 patients with hairy cell leukaemia in a tertiary care centre of north India
title Haematological profile of 21 patients with hairy cell leukaemia in a tertiary care centre of north India
title_full Haematological profile of 21 patients with hairy cell leukaemia in a tertiary care centre of north India
title_fullStr Haematological profile of 21 patients with hairy cell leukaemia in a tertiary care centre of north India
title_full_unstemmed Haematological profile of 21 patients with hairy cell leukaemia in a tertiary care centre of north India
title_short Haematological profile of 21 patients with hairy cell leukaemia in a tertiary care centre of north India
title_sort haematological profile of 21 patients with hairy cell leukaemia in a tertiary care centre of north india
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4683827/
https://www.ncbi.nlm.nih.gov/pubmed/26609034
http://dx.doi.org/10.4103/0971-5916.169204
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