Development and validation of a high throughput, closed tube method for the determination of haemoglobin alpha gene (HBA1 and HBA2) numbers by gene ratio assay copy enumeration-PCR (GRACE-PCR)

BACKGROUND: Deletions of the α-globin genes are the most common genetic abnormalities in the world. Currently multiplex Gap-PCRs are frequently used to identify specific sets of common deletions. However, these assays require significant post-amplification hands on time and cannot be used to identif...

Descripción completa

Detalles Bibliográficos
Autores principales: Turner, Andrew, Sasse, Jurgen, Varadi, Aniko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Technical Advance
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4683937/
https://www.ncbi.nlm.nih.gov/pubmed/26683685
http://dx.doi.org/10.1186/s12881-015-0258-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4683937/
https://www.ncbi.nlm.nih.gov/pubmed/26683685
http://dx.doi.org/10.1186/s12881-015-0258-y

Ejemplares similares