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Single Amino Acid Switch between a Flavin-Dependent Dehalogenase and Nitroreductase
[Image: see text] A single mutation within a flavoprotein is capable of switching the catalytic activity of a dehalogenase into a nitroreductase. This change in function correlates with a destabilization of the one-electron-reduced flavin semiquinone that is differentially expressed in the nitro-FMN...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical
Society
2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4684082/ https://www.ncbi.nlm.nih.gov/pubmed/26616824 http://dx.doi.org/10.1021/jacs.5b07540 |