Reduced number of axonal mitochondria and tau hypophosphorylation in mouse P301L tau knockin neurons

Expression of the frontotemporal dementia-related tau mutation, P301L, at physiological levels in adult mouse brain (KI-P301L mice) results in overt hypophosphorylation of tau and age-dependent alterations in axonal mitochondrial transport in peripheral nerves. To determine the effects of P301L tau...

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Detalles Bibliográficos
Autores principales: Rodríguez-Martín, Teresa, Pooler, Amy M., Lau, Dawn H.W., Mórotz, Gábor M., De Vos, Kurt J., Gilley, Jonathan, Coleman, Michael P., Hanger, Diane P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Academic Press 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4684147/
https://www.ncbi.nlm.nih.gov/pubmed/26459111
http://dx.doi.org/10.1016/j.nbd.2015.10.007

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4684147/
https://www.ncbi.nlm.nih.gov/pubmed/26459111
http://dx.doi.org/10.1016/j.nbd.2015.10.007

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