Erythroid-Specific Expression of LIN28A Is Sufficient for Robust Gamma-Globin Gene and Protein Expression in Adult Erythroblasts

Increasing fetal hemoglobin (HbF) levels in adult humans remains an active area in hematologic research. Here we explored erythroid-specific LIN28A expression for its effect in regulating gamma-globin gene expression and HbF levels in cultured adult erythroblasts. For this purpose, lentiviral transd...

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Detalles Bibliográficos
Autores principales: Lee, Y. Terry, de Vasconcellos, Jaira F., Byrnes, Colleen, Kaushal, Megha, Rabel, Antoinette, Tumburu, Laxminath, Allwardt, Joshua M., Miller, Jeffery L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4684222/
https://www.ncbi.nlm.nih.gov/pubmed/26675483
http://dx.doi.org/10.1371/journal.pone.0144977

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4684222/
https://www.ncbi.nlm.nih.gov/pubmed/26675483
http://dx.doi.org/10.1371/journal.pone.0144977

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