Direct Inhibition of Cellular Fatty Acid Synthase Impairs Replication of Respiratory Syncytial Virus and Other Respiratory Viruses

Fatty acid synthase (FASN) catalyzes the de novo synthesis of palmitate, a fatty acid utilized for synthesis of more complex fatty acids, plasma membrane structure, and post-translational palmitoylation of host and viral proteins. We have developed a potent inhibitor of FASN (TVB-3166) that reduces...

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Detalles Bibliográficos
Autores principales: Ohol, Yamini M., Wang, Zhaoti, Kemble, George, Duke, Gregory
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4684246/
https://www.ncbi.nlm.nih.gov/pubmed/26659560
http://dx.doi.org/10.1371/journal.pone.0144648

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4684246/
https://www.ncbi.nlm.nih.gov/pubmed/26659560
http://dx.doi.org/10.1371/journal.pone.0144648

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