mGlu2 Receptor Agonism, but Not Positive Allosteric Modulation, Elicits Rapid Tolerance towards Their Primary Efficacy on Sleep Measures in Rats

G-protein-coupled receptor (GPCR) agonists are known to induce both cellular adaptations resulting in tolerance to therapeutic effects and withdrawal symptoms upon treatment discontinuation. Glutamate neurotransmission is an integral part of sleep-wake mechanisms, which processes have translational...

Descripción completa

Detalles Bibliográficos
Autores principales: Ahnaou, Abdallah, Lavreysen, Hilde, Tresadern, Gary, Cid, Jose M., Drinkenburg, Wilhelmus H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4684355/
https://www.ncbi.nlm.nih.gov/pubmed/26658273
http://dx.doi.org/10.1371/journal.pone.0144017

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4684355/
https://www.ncbi.nlm.nih.gov/pubmed/26658273
http://dx.doi.org/10.1371/journal.pone.0144017

Ejemplares similares