Cargando…

mGlu2 Receptor Agonism, but Not Positive Allosteric Modulation, Elicits Rapid Tolerance towards Their Primary Efficacy on Sleep Measures in Rats

G-protein-coupled receptor (GPCR) agonists are known to induce both cellular adaptations resulting in tolerance to therapeutic effects and withdrawal symptoms upon treatment discontinuation. Glutamate neurotransmission is an integral part of sleep-wake mechanisms, which processes have translational...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ahnaou, Abdallah, Lavreysen, Hilde, Tresadern, Gary, Cid, Jose M., Drinkenburg, Wilhelmus H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4684355/ https://www.ncbi.nlm.nih.gov/pubmed/26658273 http://dx.doi.org/10.1371/journal.pone.0144017

Ejemplares similares

Pharmacological and pharmacokinetic properties of JNJ-40411813, a positive allosteric modulator of the mGlu2 receptor
por: Lavreysen, Hilde, et al.
Publicado: (2015)

Modulation of mGlu2 Receptors, but Not PDE10A Inhibition Normalizes Pharmacologically-Induced Deviance in Auditory Evoked Potentials and Oscillations in Conscious Rats
por: Ahnaou, Abdallah, et al.
Publicado: (2016)

Preclinical evaluation of the antipsychotic potential of the mGlu2-positive allosteric modulator JNJ-40411813
por: Lavreysen, Hilde, et al.
Publicado: (2015)

Allosteric Modulators for mGlu Receptors
por: Gasparini, F, et al.
Publicado: (2007)

Structural insights into dimerization and activation of the mGlu2–mGlu3 and mGlu2–mGlu4 heterodimers
por: Wang, Xinwei, et al.
Publicado: (2023)

Tetrahydronaphthyridine and Dihydronaphthyridinone Ethers As Positive Allosteric Modulators of the Metabotropic Glutamate Receptor 5 (mGlu(5))
por: Turlington, Mark, et al.
Publicado: (2014)

Neurobiological Insights from mGlu Receptor Allosteric Modulation
por: O’Brien, Daniel E, et al.
Publicado: (2015)

Functional Neurophysiological Biomarkers of Early-Stage Alzheimer’s Disease: A Perspective of Network Hyperexcitability in Disease Progression
por: Tok, Sean, et al.
Publicado: (2022)

mGlu(5) Positive Allosteric Modulators Facilitate Long-Term Potentiation via Disinhibition Mediated by mGlu(5)-Endocannabinoid Signaling
por: Xiang, Zixiu, et al.
Publicado: (2019)

Negative Allosteric Modulators of mGlu(7) Receptor as Putative Antipsychotic Drugs
por: Cieślik, Paulina, et al.
Publicado: (2018)

Differential activity of mGlu(7) allosteric modulators provides evidence for mGlu(7/8) heterodimers at hippocampal Schaffer collateral-CA1 synapses
por: Lin, Xin, et al.
Publicado: (2022)

Challenges in the Discovery and Optimization of mGlu(2/4) Heterodimer Positive Allosteric Modulators
por: Fulton, Mark Gallant, et al.
Publicado: (2019)

mGlu2 metabotropic glutamate receptors restrain inflammatory pain and mediate the analgesic activity of dual mGlu2/mGlu3 receptor agonists
por: Zammataro, Magda, et al.
Publicado: (2011)

Discovery of a Novel Chemical Class of mGlu(5) Allosteric Ligands with Distinct Modes of Pharmacology
por: Hammond, Alexis S., et al.
Publicado: (2010)

Optical control of pain in vivo with a photoactive mGlu(5) receptor negative allosteric modulator
por: Font, Joan, et al.
Publicado: (2017)

Scaffold Hopping to Imidazo[1,2-a]pyrazin-8-one Positive Allosteric Modulators of Metabotropic Glutamate 2 Receptor
por: de Lucas, Ana I., et al.
Publicado: (2021)

NMDARs Containing NR2B Subunit Do Not Contribute to the LTP Form of Hippocampal Plasticity: In Vivo Pharmacological Evidence in Rats
por: Ahnaou, Abdallah, et al.
Publicado: (2021)

Covalent Allosteric Probe for the Metabotropic Glutamate Receptor 2: Design, Synthesis, and Pharmacological Characterization
por: Doornbos, Maarten L. J., et al.
Publicado: (2018)

Allosteric nanobodies uncover a role of hippocampal mGlu2 receptor homodimers in contextual fear consolidation
por: Scholler, Pauline, et al.
Publicado: (2017)

Correction: Optical control of pain in vivo with a photoactive mGlu5 receptor negative allosteric modulator
por: Font, Joan, et al.
Publicado: (2018)

Decreased striatal dopamine in group II metabotropic glutamate receptor (mGlu2/mGlu3) double knockout mice
por: Lane, Tracy A, et al.
Publicado: (2013)

Emotional Impairment and Persistent Upregulation of mGlu(5) Receptor following Morphine Abstinence: Implications of an mGlu(5)-MOPr Interaction
por: Zanos, Panos, et al.
Publicado: (2016)

mGlu1 Receptors Monopolize the Synaptic Control of Cerebellar Purkinje Cells by Epigenetically Down-Regulating mGlu5 Receptors
por: Notartomaso, Serena, et al.
Publicado: (2018)

Negative allosteric modulation of the mGlu7 receptor reduces visceral hypersensitivity in a stress-sensitive rat strain
por: Moloney, Rachel D., et al.
Publicado: (2015)

Deletion of Metabotropic Glutamate Receptors 2 and 3 (mGlu2 & mGlu3) in Mice Disrupts Sleep and Wheel-Running Activity, and Increases the Sensitivity of the Circadian System to Light
por: Pritchett, David, et al.
Publicado: (2015)

mGlu5 Receptor Functional Interactions and Addiction
por: Brown, Robyn M., et al.
Publicado: (2012)

Partial mGlu(5) Negative Allosteric Modulator M-5MPEP Demonstrates Antidepressant-Like Effects on Sleep Without Affecting Cognition or Quantitative EEG
por: Holter, Kimberly M., et al.
Publicado: (2021)

The Role of mGlu Receptors in Hippocampal Plasticity Deficits in Neurological and Psychiatric Disorders: Implications for Allosteric Modulators as Novel Therapeutic Strategies
por: Senter, Rebecca K., et al.
Publicado: (2016)

Functional Alterations in the Olfactory Neuronal Circuit Occur before Hippocampal Plasticity Deficits in the P301S Mouse Model of Tauopathy: Implications for Early Diagnosis and Translational Research in Alzheimer’s Disease
por: Ahnaou, Abdallah, et al.
Publicado: (2020)

Exploring the Activation Mechanism of the mGlu5 Transmembrane Domain
por: Lans, Isaias, et al.
Publicado: (2020)

Regulation and functional consequences of mGlu(4) RNA editing
por: Hofmann, Christopher S., et al.
Publicado: (2021)

Potentiation of sensory responses in ventrobasal thalamus in vivo via selective modulation of mGlu1 receptors with a positive allosteric modulator
por: Salt, T.E., et al.
Publicado: (2012)

Evaluation of Synthetic Cytochrome P(450)-Mimetic Metalloporphyrins To Facilitate “Biomimetic” Biotransformation of a Series of mGlu(5) Allosteric Ligands
por: Presley, Christopher C., et al.
Publicado: (2019)

The role of water and protein flexibility in the structure-based virtual screening of allosteric GPCR modulators: an mGlu(5) receptor case study
por: Orgován, Zoltán, et al.
Publicado: (2019)

The operational model of allosteric modulation of pharmacological agonism
por: Jakubík, Jan, et al.
Publicado: (2020)

Differential Modulation of Thresholds for Intracranial Self-Stimulation by mGlu5 Positive and Negative Allosteric Modulators: Implications for Effects on Drug Self-Administration
por: Cleva, Richard M., et al.
Publicado: (2012)

In Vivo Non-radioactive Assessment of mGlu5 Receptor-Activated Polyphosphoinositide Hydrolysis in Response to Systemic Administration of a Positive Allosteric Modulator
por: Zuena, Anna R., et al.
Publicado: (2018)

Function of mGlu1 receptors in the modulation of nociceptive processing in the thalamus()
por: Salt, T.E., et al.
Publicado: (2014)

Structural insights into the activation initiation of full-length mGlu1
por: Zhang, Jinyi, et al.
Publicado: (2020)

mGlu2 mechanism-based interventions to treat alcohol relapse
por: Vengeliene, Valentina, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_q76oq93vcjvooeefc9leo5kl1m