Delayed Induction of Human NTE (PNPLA6) Rescues Neurodegeneration and Mobility Defects of Drosophila swiss cheese (sws) Mutants

Human PNPLA6 gene encodes Neuropathy Target Esterase protein (NTE). PNPLA6 gene mutations cause hereditary spastic paraplegia (SPG39 HSP), Gordon-Holmes syndrome, Boucher-Neuhäuser syndromes, Laurence-Moon syndrome, and Oliver-McFarlane syndrome. Mutations in the Drosophila NTE homolog swiss cheese...

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Detalles Bibliográficos
Autores principales: Sujkowski, Alyson, Rainier, Shirley, Fink, John K., Wessells, Robert J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4684404/
https://www.ncbi.nlm.nih.gov/pubmed/26671664
http://dx.doi.org/10.1371/journal.pone.0145356

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4684404/
https://www.ncbi.nlm.nih.gov/pubmed/26671664
http://dx.doi.org/10.1371/journal.pone.0145356

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