Structural interplay between germline and adaptive recognition determines TCR-peptide-MHC cross-reactivity

The T cell receptor - peptide-MHC interface is comprised of conserved and diverse regions, yet the relative contributions of each in shaping T cell recognition remain unclear. We isolated cross-reactive peptides with limited homology, allowing us to compare the structural properties of nine peptides...

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Detalles Bibliográficos
Autores principales: Adams, Jarrett J., Narayanan, Samanthi, Birnbaum, Michael E., Sidhu, Sachdev S., Blevins, Sydney J., Gee, Marvin H., Sibener, Leah V., Baker, Brian M., Kranz, David M., Garcia, K. Christopher
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4684756/
https://www.ncbi.nlm.nih.gov/pubmed/26523866
http://dx.doi.org/10.1038/ni.3310

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4684756/
https://www.ncbi.nlm.nih.gov/pubmed/26523866
http://dx.doi.org/10.1038/ni.3310

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