Cargando…

Activation of the Mammalian Target of Rapamycin in the Rostral Ventromedial Medulla Contributes to the Maintenance of Nerve Injury-Induced Neuropathic Pain in Rat

The mammalian target of rapamycin (mTOR), a serine-threonine protein kinase, integrates extracellular signals, thereby modulating several physiological and pathological processes, including pain. Previous studies have suggested that rapamycin (an mTOR inhibitor) can attenuate nociceptive behaviors i...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Jian, Feng, Da-Yun, Li, Zhi-Hua, Feng, Ban, Zhang, Han, Zhang, Ting, Chen, Tao, Li, Yun-Qing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4684879/ https://www.ncbi.nlm.nih.gov/pubmed/26770837 http://dx.doi.org/10.1155/2015/394820

Ejemplares similares

The Role of The Rostral Ventromedial Medulla in Stress Responses
por: Pagliusi, Marco, et al.
Publicado: (2023)

G protein‐coupled estrogen receptor in the rostral ventromedial medulla contributes to the chronification of postoperative pain
por: Xu, Jia‐Jia, et al.
Publicado: (2021)

Effect of Exercise on µ-Opioid Receptor Expression in the Rostral Ventromedial Medulla in Neuropathic Pain Rat Model
por: Kim, Young-Jin, et al.
Publicado: (2015)

Neurochemical properties of BDNF-containing neurons projecting to rostral ventromedial medulla in the ventrolateral periaqueductal gray
por: Yin, Jun-Bin, et al.
Publicado: (2014)

Morphological evidence for a neurotensinergic periaqueductal gray-rostral ventromedial medulla-spinal dorsal horn descending pathway in rat
por: Wang, Jian, et al.
Publicado: (2014)

Trigeminal-Rostral Ventromedial Medulla circuitry is involved in orofacial hyperalgesia contralateral to tissue injury
por: Chai, Bryan, et al.
Publicado: (2012)

Orexin-A Modulates Firing of Rat Rostral Ventromedial Medulla Neurons: An In Vitro Study
por: Azhdari-Zarmehri, Hassan, et al.
Publicado: (2015)

The locus coeruleus input to the rostral ventromedial medulla mediates stress-induced colorectal visceral pain
por: Kong, Dexu, et al.
Publicado: (2023)

EP1 receptor within the ventrolateral periaqueductal grey controls thermonociception and rostral ventromedial medulla cell activity in healthy and neuropathic rat
por: Palazzo, Enza, et al.
Publicado: (2011)

Tail Flick Modification of Orexin-A Induced Changes of Electrophysiological Parameters in The Rostral Ventromedial Medulla
por: Azhdari-Zarmehri, Hassan, et al.
Publicado: (2014)

Permanent lesion in rostral ventromedial medulla potentiates swim stress-induced analgesia in formalin test
por: Shamsizadeh, Ali, et al.
Publicado: (2014)

NAAG peptidase inhibition in the periaqueductal gray and rostral ventromedial medulla reduces flinching in the formalin model of inflammation
por: Yamada, Toshihiko, et al.
Publicado: (2012)

Physiological properties of pain-modulating neurons in rostral ventromedial medulla in female rats, and responses to opioid administration
por: Hryciw, Gwen, et al.
Publicado: (2021)

Inhibition of itch by neurokinin 1 receptor (Tacr1) -expressing ON cells in the rostral ventromedial medulla in mice
por: Follansbee, Taylor, et al.
Publicado: (2022)

Administration of orexin receptor 1 antagonist into the rostral ventromedial medulla increased swim stress-induced antinociception in rat
por: Soliemani, Neda, et al.
Publicado: (2016)

Shifting the Balance: How Top-Down and Bottom-Up Input Modulate Pain via the Rostral Ventromedial Medulla
por: Chen, Qiliang, et al.
Publicado: (2022)

The Rostral Ventromedial and Lateral Medulla Are the Major Areas Responsive to Lung Cancer Progression among Brainstem Lung-Innervating Nuclei
por: Chen, Mo, et al.
Publicado: (2022)

Enhancement in Tonically Active Glutamatergic Inputs to the Rostral Ventrolateral Medulla Contributes to Neuropathic Pain-Induced High Blood Pressure
por: Wang, Wei, et al.
Publicado: (2017)

Kappa opioids inhibit the GABA/glycine terminals of rostral ventromedial medulla projections in the superficial dorsal horn of the spinal cord
por: Otsu, Yo, et al.
Publicado: (2022)

Systemically administered neurotensin receptor agonist produces antinociception through activation of spinally projecting serotonergic neurons in the rostral ventromedial medulla
por: Li, Yaqun, et al.
Publicado: (2021)

Selective Ablation of Descending Serotonin from the Rostral Ventromedial Medulla Unmasks Its Pro-Nociceptive Role in Chemotherapy-Induced Painful Neuropathy
por: Liu, Xijiang, et al.
Publicado: (2020)

Optogenetic Evidence for a Direct Circuit Linking Nociceptive Transmission through the Parabrachial Complex with Pain-Modulating Neurons of the Rostral Ventromedial Medulla (RVM)
por: Chen, QiLiang, et al.
Publicado: (2017)

Descending serotonergic modulation from rostral ventromedial medulla to spinal trigeminal nucleus is involved in experimental occlusal interference-induced chronic orofacial hyperalgesia
por: Mo, Si-Yi, et al.
Publicado: (2023)

Oxidative Stress in the Rostral Ventrolateral Medulla Contributes To Cardiovascular Regulation in Preeclampsia
por: Yan, Jiu-Qiong, et al.
Publicado: (2017)

Regular physical activity reduces the percentage of spinally projecting neurons that express mu-opioid receptors from the rostral ventromedial medulla in mice
por: Sluka, Kathleen A., et al.
Publicado: (2020)

Attenuation of hyperalgesia responses via the modulation of 5-hydroxytryptamine signalings in the rostral ventromedial medulla and spinal cord in a 6-hydroxydopamine-induced rat model of Parkinson’s disease
por: Wang, Chen-Tao, et al.
Publicado: (2017)

Anxiety-induced hyperalgesia in female rats is mediated by cholecystokinin 2 receptor in rostral ventromedial medulla and spinal 5-hydroxytryptamine 2B receptor
por: Jiang, Ming, et al.
Publicado: (2019)

Peripheral inflammatory injury alters the relative abundance of Gα subunits in the dorsal horn of the spinal cord and in the rostral ventromedial medulla of male rats
por: Wattiez, Anne-Sophie, et al.
Publicado: (2017)

Activation of Astrocytes and Microglial Cells and CCL2/CCR2 Upregulation in the Dorsolateral and Ventrolateral Nuclei of Periaqueductal Gray and Rostral Ventromedial Medulla Following Different Types of Sciatic Nerve Injury
por: Dubový, Petr, et al.
Publicado: (2018)

Importance of rostral ventrolateral medulla neurons in determining efferent sympathetic nerve activity and blood pressure
por: Kumagai, Hiroo, et al.
Publicado: (2012)

Injury induced activation of extracellular signal-regulated kinase (ERK) in the rat rostral ventromedial medulla (RVM) is age dependant and requires the lamina I projection pathway
por: Géranton, Sandrine M, et al.
Publicado: (2010)

Effects of a metabotropic glutamate receptor subtype 7 negative allosteric modulator in the periaqueductal grey on pain responses and rostral ventromedial medulla cell activity in rat
por: Palazzo, Enza, et al.
Publicado: (2013)

Neuroinflammation contributes to autophagy flux blockage in the neurons of rostral ventrolateral medulla in stress-induced hypertension rats
por: Du, Dongshu, et al.
Publicado: (2017)

Hypoxic chemosensitivity of the cardiorespiratory regions of the rostral ventrolateral medulla (RVLM)
por: D'Agostino, D, et al.
Publicado: (2001)

Revisiting differential control of sympathetic outflow by the rostral ventrolateral medulla
por: Kulkarni, Soumya S., et al.
Publicado: (2023)

Neuroinflammation and oxidative stress in rostral ventrolateral medulla contribute to neurogenic hypertension induced by systemic inflammation
por: Wu, Kay LH, et al.
Publicado: (2012)

Leptin into the rostral ventral lateral medulla (RVLM) augments renal sympathetic nerve activity and blood pressure
por: Barnes, Maria J., et al.
Publicado: (2014)

The chronification mechanism of orofacial inflammatory pain: Facilitation by GPER1 and microglia in the rostral ventral medulla
por: Zheng, Wenwen, et al.
Publicado: (2023)

Orexin Receptor-1 in the Rostral Ventrolateral Medulla Mediates the Antihypertensive Effects of Electroacupuncture
por: Tan, Ying-Ying, et al.
Publicado: (2019)

Role of the Rostral Ventrolateral Medulla in the Arterial Hypertension in Chronic Renal Failure
por: Dugaich, Adriana P. Castilho, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_cmbacgp9ji7bhq8mhc3hsdaknq