“Mouse Clone Model” for evaluating the immunogenicity and tumorigenicity of pluripotent stem cells

To investigate the immune-rejection and tumor-formation potentials of induced pluripotent stem cells and other stem cells, we devised a model—designated the “Mouse Clone Model”—which combined the theory of somatic animal cloning, tetraploid complementation, and induced pluripotent stem cells to demo...

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Detalles Bibliográficos
Autores principales: Zhang, Gang, Zhang, Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Viewpoint
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4684929/
https://www.ncbi.nlm.nih.gov/pubmed/26687081
http://dx.doi.org/10.1186/s13287-015-0262-3
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author Zhang, Gang
Zhang, Yi
author_facet Zhang, Gang
Zhang, Yi
author_sort Zhang, Gang
collection PubMed
description To investigate the immune-rejection and tumor-formation potentials of induced pluripotent stem cells and other stem cells, we devised a model—designated the “Mouse Clone Model”—which combined the theory of somatic animal cloning, tetraploid complementation, and induced pluripotent stem cells to demonstrate the applicability of stem cells for transplantation therapy.
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spelling pubmed-46849292015-12-21 “Mouse Clone Model” for evaluating the immunogenicity and tumorigenicity of pluripotent stem cells Zhang, Gang Zhang, Yi Stem Cell Res Ther Viewpoint To investigate the immune-rejection and tumor-formation potentials of induced pluripotent stem cells and other stem cells, we devised a model—designated the “Mouse Clone Model”—which combined the theory of somatic animal cloning, tetraploid complementation, and induced pluripotent stem cells to demonstrate the applicability of stem cells for transplantation therapy. BioMed Central 2015-12-18 /pmc/articles/PMC4684929/ /pubmed/26687081 http://dx.doi.org/10.1186/s13287-015-0262-3 Text en © Zhang and Zhang. 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Viewpoint
Zhang, Gang
Zhang, Yi
“Mouse Clone Model” for evaluating the immunogenicity and tumorigenicity of pluripotent stem cells
title “Mouse Clone Model” for evaluating the immunogenicity and tumorigenicity of pluripotent stem cells
title_full “Mouse Clone Model” for evaluating the immunogenicity and tumorigenicity of pluripotent stem cells
title_fullStr “Mouse Clone Model” for evaluating the immunogenicity and tumorigenicity of pluripotent stem cells
title_full_unstemmed “Mouse Clone Model” for evaluating the immunogenicity and tumorigenicity of pluripotent stem cells
title_short “Mouse Clone Model” for evaluating the immunogenicity and tumorigenicity of pluripotent stem cells
title_sort “mouse clone model” for evaluating the immunogenicity and tumorigenicity of pluripotent stem cells
topic Viewpoint
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4684929/
https://www.ncbi.nlm.nih.gov/pubmed/26687081
http://dx.doi.org/10.1186/s13287-015-0262-3
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