NRF2 Regulates HER2 and HER3 Signaling Pathway to Modulate Sensitivity to Targeted Immunotherapies

NF-E2 related factor-2 (NRF2) is an essential transcription factor for multiple genes encoding antioxidants and detoxification enzymes. NRF2 is implicated in promoting cancer therapeutic resistance by its detoxification function and crosstalk with proproliferative pathways. However, the exact mechan...

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Detalles Bibliográficos
Autores principales: Khalil, Hilal S., Langdon, Simon P., Kankia, Ibrahim H., Bown, James, Deeni, Yusuf Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4685121/
https://www.ncbi.nlm.nih.gov/pubmed/26770651
http://dx.doi.org/10.1155/2016/4148791

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4685121/
https://www.ncbi.nlm.nih.gov/pubmed/26770651
http://dx.doi.org/10.1155/2016/4148791

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