G9a orchestrates PCL3 and KDM7A to promote histone H3K27 methylation

Methylation of histone H3-lysine 9 (H3K9) and H3K27 by the methyltransferase G9a and polycomb repressive complex 2 (PRC2) inhibits transcription of target genes. A crosstalk between G9a and PRC2 via direct physical interaction has been shown recently. Here, we demonstrate an alternative mechanism by...

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Detalles Bibliográficos
Autores principales: Pan, Mei-Ren, Hsu, Ming-Chuan, Chen, Li-Tzong, Hung, Wen-Chun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4685317/
https://www.ncbi.nlm.nih.gov/pubmed/26688070
http://dx.doi.org/10.1038/srep18709

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4685317/
https://www.ncbi.nlm.nih.gov/pubmed/26688070
http://dx.doi.org/10.1038/srep18709

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