Structural determinants of reductive terpene cyclization in iridoid biosynthesis

The carbon skeleton of ecologically and pharmacologically important iridoid monoterpenes is formed in a reductive cyclization reaction unrelated to canonical terpene cyclization. Here we report the crystal structure of the recently discovered iridoid cyclase (Catharanthus roseus) bound to a mechanis...

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Detalles Bibliográficos
Autores principales: Kries, Hajo, Caputi, Lorenzo, Stevenson, Clare E. M., Kamileen, Mohammed O., Sherden, Nathaniel H., Geu-Flores, Fernando, Lawson, David M., O’Connor, Sarah E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4685742/
https://www.ncbi.nlm.nih.gov/pubmed/26551396
http://dx.doi.org/10.1038/nchembio.1955

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4685742/
https://www.ncbi.nlm.nih.gov/pubmed/26551396
http://dx.doi.org/10.1038/nchembio.1955

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