Cargando…

Diversity-oriented synthesis of analogues of the novel macrocyclic peptide FR-225497 through late stage functionalization

A concise synthetic approach to a class of biologically interesting cyclic tetrapeptides is reported which involves a late-stage functionalization of a macrocyclic scaffold through cross metathesis in an attempt to create diversity. The utility of this protocol is demonstrated through the preparatio...

Descripción completa

Detalles Bibliográficos
Autores principales: Mukherjee, Jyotiprasad, Sil, Suman, Chattopadhyay, Shital Kumar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4685926/
https://www.ncbi.nlm.nih.gov/pubmed/26734096
http://dx.doi.org/10.3762/bjoc.11.270