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Diversity-oriented synthesis of analogues of the novel macrocyclic peptide FR-225497 through late stage functionalization
A concise synthetic approach to a class of biologically interesting cyclic tetrapeptides is reported which involves a late-stage functionalization of a macrocyclic scaffold through cross metathesis in an attempt to create diversity. The utility of this protocol is demonstrated through the preparatio...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Beilstein-Institut
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4685926/ https://www.ncbi.nlm.nih.gov/pubmed/26734096 http://dx.doi.org/10.3762/bjoc.11.270 |