Rosiglitazone Suppresses In Vitro Seizures in Hippocampal Slice by Inhibiting Presynaptic Glutamate Release in a Model of Temporal Lobe Epilepsy

Peroxisomal proliferator-activated receptor gamma (PPARγ) is a nuclear hormone receptor whose agonist, rosiglitazone has a neuroprotective effect to hippocampal neurons in pilocarpine-induced seizures. Hippocampal slice preparations treated in Mg(2+) free medium can induce ictal and interictal-like...

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Detalles Bibliográficos
Autores principales: Wong, Shi-Bing, Cheng, Sin-Jhong, Hung, Wei-Chen, Lee, Wang-Tso, Min, Ming-Yuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4685987/
https://www.ncbi.nlm.nih.gov/pubmed/26659605
http://dx.doi.org/10.1371/journal.pone.0144806

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4685987/
https://www.ncbi.nlm.nih.gov/pubmed/26659605
http://dx.doi.org/10.1371/journal.pone.0144806

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