Dysregulation of the DNA Damage Response and KMT2A Rearrangement in Fetal Liver Hematopoietic Cells

Etoposide, a topoisomerase 2 (TOP2) inhibitor, is associated with the development of KMT2A (MLL)-rearranged infant leukemia. An epidemiological study suggested that in utero exposure to TOP2 inhibitors may be involved in generation of KMT2A (MLL) rearrangement. The present study examined the mechani...

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Detalles Bibliográficos
Autores principales: Nanya, Mai, Sato, Masaki, Tanimoto, Kousuke, Tozuka, Minoru, Mizutani, Shuki, Takagi, Masatoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4686171/
https://www.ncbi.nlm.nih.gov/pubmed/26657054
http://dx.doi.org/10.1371/journal.pone.0144540

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4686171/
https://www.ncbi.nlm.nih.gov/pubmed/26657054
http://dx.doi.org/10.1371/journal.pone.0144540

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