Chemogenomic Study of Carboplatin in Saccharomyces cerevisiae: Inhibition of the NEDDylation Process Overcomes Cellular Resistance Mediated by HuR and Cullin Proteins

The use of carboplatin in cancer chemotherapy is limited by the emergence of drug resistance. To understand the molecular basis for this resistance, a chemogenomic screen was performed in 53 yeast mutants that had previously presented strong sensitivity to this widely used anticancer agent. Thirty-f...

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Detalles Bibliográficos
Autores principales: de Sousa, Graziele Fonseca, Lima, Maira de Assis, Custodio, Débora Fernandes, Freitas, Vanessa Morais, Monteiro, Gisele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4686384/
https://www.ncbi.nlm.nih.gov/pubmed/26692264
http://dx.doi.org/10.1371/journal.pone.0145377

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4686384/
https://www.ncbi.nlm.nih.gov/pubmed/26692264
http://dx.doi.org/10.1371/journal.pone.0145377

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