Disturbances of Ligand Potency and Enhanced Degradation of the Human Glycine Receptor at Affected Positions G160 and T162 Originally Identified in Patients Suffering from Hyperekplexia

Ligand-binding of Cys-loop receptors is determined by N-terminal extracellular loop structures from the plus as well as from the minus side of two adjacent subunits in the pentameric receptor complex. An aromatic residue in loop B of the glycine receptor (GlyR) undergoes direct interaction with the...

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Detalles Bibliográficos
Autores principales: Atak, Sinem, Langlhofer, Georg, Schaefer, Natascha, Kessler, Denise, Meiselbach, Heike, Delto, Carolyn, Schindelin, Hermann, Villmann, Carmen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4686643/
https://www.ncbi.nlm.nih.gov/pubmed/26733802
http://dx.doi.org/10.3389/fnmol.2015.00079

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4686643/
https://www.ncbi.nlm.nih.gov/pubmed/26733802
http://dx.doi.org/10.3389/fnmol.2015.00079

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