Cargando…

SF3B1 mutant MDS-initiating cells may arise from the haematopoietic stem cell compartment

Despite the recent evidence of the existence of myelodysplastic syndrome (MDS) stem cells in 5q-MDS patients, it is unclear whether haematopoietic stem cells (HSCs) could also be the initiating cells in other MDS subgroups. Here we demonstrate that SF3B1 mutation(s) in our cohort of MDS patients wit...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mian, Syed A., Rouault-Pierre, Kevin, Smith, Alexander E., Seidl, Thomas, Pizzitola, Irene, Kizilors, Aytug, Kulasekararaj, Austin G., Bonnet, Dominique, Mufti, Ghulam J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4686651/ https://www.ncbi.nlm.nih.gov/pubmed/26643973 http://dx.doi.org/10.1038/ncomms10004

Ejemplares similares

Mixed T cell lineage chimerism in acute leukemia/MDS using pre-emptive donor lymphocyte infusion strategy—Is it prognostic?—a single-center retrospective study
por: Sheth, Vipul, et al.
Publicado: (2021)

P1411: DUAL EPIGENETIC AND GENETIC EDITING OF PRIMARY HUMAN HAEMATOPOIETIC STEM AND PROGENITOR CELLS
por: Saunderson, E., et al.
Publicado: (2022)

The Role of Early Molecular Response in the Management of Chronic Phase CML
por: Harrington, Patrick, et al.
Publicado: (2017)

RPL27A is a target of miR-595 and may contribute to the myelodysplastic phenotype through ribosomal dysgenesis
por: Alkhatabi, Heba A., et al.
Publicado: (2016)

Allogeneic haematopoietic stem cell transplantation resets T‐ and B‐cell compartments in sickle cell disease patients
por: Jarduli‐Maciel, Luciana Ribeiro, et al.
Publicado: (2022)

Expansion of myeloid derived suppressor cells correlates with number of T regulatory cells and disease progression in myelodysplastic syndrome
por: Kittang, Astrid Olsnes, et al.
Publicado: (2015)

Patient-specific MDS-RS iPSCs define the mis-spliced transcript repertoire and chromatin landscape of SF3B1-mutant HSPCs
por: Asimomitis, Georgios, et al.
Publicado: (2022)

A novel SF3B1 variant in a patient with MDS with ring sideroblasts
por: Al‐Ghamdi, Yahya A., et al.
Publicado: (2022)

The E592K variant of SF3B1 creates unique RNA missplicing and associates with high-risk MDS without ring sideroblasts
por: Choi, In Young, et al.
Publicado: (2023)

Cell cycle dynamics and complement expression distinguishes mature haematopoietic subsets arising from hemogenic endothelium
por: Zape, Joan P., et al.
Publicado: (2017)

SF3B1 mutations induce R-loop accumulation and DNA damage in MDS and leukemia cells with therapeutic implications
por: Singh, Shalini, et al.
Publicado: (2020)

Valuation of transfusion-free living in MDS: results of health utility interviews with patients
por: Szende, Agota, et al.
Publicado: (2009)

GEP analysis validates high risk MDS and acute myeloid leukemia post MDS mice models and highlights novel dysregulated pathways
por: Guerenne, Laura, et al.
Publicado: (2016)

SF3B1 mutated MDS: Blast count, genetic co-abnormalities and their impact on classification and prognosis
por: Huber, Sandra, et al.
Publicado: (2022)

Contribution of mutant HSC clones to immature and mature cells in MDS and CMML, and variations with AZA therapy
por: Schnegg-Kaufmann, Annatina S., et al.
Publicado: (2023)

Malcovati L, Stevenson K, Papaemmanuil E, et al. SF3B1-mutant MDS as a distinct disease subtype: a proposal from the International Working Group for the Prognosis of MDS. Blood. 2020;136(2):157-170.
Publicado: (2021)

B-RAF Mutant Alleles Associated with Langerhans Cell Histiocytosis, a Granulomatous Pediatric Disease
por: Satoh, Takeshi, et al.
Publicado: (2012)

Myelo-lymphoid lineage restriction occurs in the human haematopoietic stem cell compartment before lymphoid-primed multipotent progenitors
por: Belluschi, Serena, et al.
Publicado: (2018)

Human Erythroid Progenitors Are Directly Infected by SARS-CoV-2: Implications for Emerging Erythropoiesis in Severe COVID-19 Patients
por: Huerga Encabo, Hector, et al.
Publicado: (2021)

SF3B1 mutations in AML are strongly associated with MECOM rearrangements and may be indicative of an MDS pre-phase
por: Huber, Sandra, et al.
Publicado: (2022)

The extent of residual WT HSPCs is associated with the degree of anemia in patients with SF3B1-mutated MDS-RS
por: Hofman, Isabel Juliana F., et al.
Publicado: (2022)

Correction: B-RAF Mutant Alleles Associated with Langerhans Cell Histiocytosis, a Granulomatous Pediatric Disease
por: Satoh, Takeshi, et al.
Publicado: (2012)

Proliferative activity is disturbed in myeloproliferative neoplasms (MPN), myelodysplastic syndrome (MDS), and MDS/MPN diseases. Differences between MDS and MDS/MPN
por: Mestrum, Stefan G. C., et al.
Publicado: (2020)

Downregulation of MMP1 in MDS-derived mesenchymal stromal cells reduces the capacity to restrict MDS cell proliferation
por: Zhao, Sida, et al.
Publicado: (2017)

The Haematopoietic Stem Cell Niche: New Insights into the Mechanisms Regulating Haematopoietic Stem Cell Behaviour
por: Lilly, Andrew J., et al.
Publicado: (2011)

Somatic mutations in SF3B1 aberrant‐negative MDS‐RS most commonly involved in TP53 genes
por: Li, Xiao, et al.
Publicado: (2022)

Preclinical modeling of myelodysplastic syndromes
por: Rouault-Pierre, K, et al.
Publicado: (2017)

Expansion of Haematopoietic Stem and Progenitor Cells: Paving the Way for Next-Generation Haematopoietic Stem Cell Transplantation
por: Bari, Sudipto, et al.
Publicado: (2019)

Recapitulative haematopoietic development of human pluripotent stem cells in the absence of exogenous haematopoietic cytokines
por: Philonenko, Elena S., et al.
Publicado: (2021)

Hematopoietic Cell Transplantation for Older Patients with MDS
por: Shadman, Mazyar, et al.
Publicado: (2014)

Standardizing haematopoietic cell transplants in China
por: Gale, Robert Peter
Publicado: (2018)

Clonality in haematopoietic stem cell ageing
por: Terradas-Terradas, Maria, et al.
Publicado: (2020)

The significance of aminopeptidases and haematopoietic cell differentiation
por: Razak, K, et al.
Publicado: (1992)

Neutrophil and platelet increases with luspatercept in lower-risk MDS: secondary endpoints from the MEDALIST trial
por: Garcia-Manero, Guillermo, et al.
Publicado: (2022)

Different mutant RUNX1 oncoproteins program alternate haematopoietic differentiation trajectories
por: Kellaway, Sophie G, et al.
Publicado: (2021)

Despite mutation acquisition in hematopoietic stem cells, JMML-propagating cells are not always restricted to this compartment
por: Caye, Aurélie, et al.
Publicado: (2019)

SF3B1 deficiency impairs human erythropoiesis via activation of p53 pathway: implications for understanding of ineffective erythropoiesis in MDS
por: Huang, Yumin, et al.
Publicado: (2018)

Mutant SF3B1 promotes malignancy in PDAC
por: Simmler, Patrik, et al.
Publicado: (2023)

Correction: Despite mutation acquisition in hematopoietic stem cells, JMML-propagating cells are not always restricted to this compartment
por: Caye, Aurélie, et al.
Publicado: (2020)

P1288: UNMANIPULATED PERIPHERAL HAPLOIDENTICAL HAEMATOPOIETIC STEM CELL TRANSPLANT IS AN EFFECTIVE CONSOLIDATIVE STRATEGY FOR HIGH-RISK ACUTE MYELOID LEUKAEMIA AND MYELODYSPLASTIC SYNDROME
por: Serpenti, Fabio, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_ui1k1b4sc6ra1utq9k93bs524g