A molecular ruler regulates cytoskeletal remodelling by the Rho kinases

The Rho-associated coiled-coil kinases (ROCK) are essential regulators of the actin cytoskeleton; however, the structure of a full-length ROCK is unknown and the mechanisms by which its kinase activity is controlled are not well understood. Here we determine the low-resolution structure of human ROC...

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Detalles Bibliográficos
Autores principales: Truebestein, Linda, Elsner, Daniel J., Fuchs, Elisabeth, Leonard, Thomas A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4686654/
https://www.ncbi.nlm.nih.gov/pubmed/26620183
http://dx.doi.org/10.1038/ncomms10029

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4686654/
https://www.ncbi.nlm.nih.gov/pubmed/26620183
http://dx.doi.org/10.1038/ncomms10029

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