A tyrosine–tryptophan dyad and radical-based charge transfer in a ribonucleotide reductase-inspired maquette

In class 1a ribonucleotide reductase (RNR), a substrate-based radical is generated in the α2 subunit by long-distance electron transfer involving an essential tyrosyl radical (Y122O·) in the β2 subunit. The conserved W48 β2 is ∼10 Å from Y122OH; mutations at W48 inactivate RNR. Here, we design a bet...

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Detalles Bibliográficos
Autores principales: Pagba, Cynthia V., McCaslin, Tyler G., Veglia, Gianluigi, Porcelli, Fernando, Yohannan, Jiby, Guo, Zhanjun, McDaniel, Miranda, Barry, Bridgette A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4686667/
https://www.ncbi.nlm.nih.gov/pubmed/26627888
http://dx.doi.org/10.1038/ncomms10010

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4686667/
https://www.ncbi.nlm.nih.gov/pubmed/26627888
http://dx.doi.org/10.1038/ncomms10010

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