Gln40 deamidation blocks structural reconfiguration and activation of SCF ubiquitin ligase complex by Nedd8

The full enzymatic activity of the cullin-RING ubiquitin ligases (CRLs) requires a ubiquitin-like protein (that is, Nedd8) modification. By deamidating Gln40 of Nedd8 to glutamate (Q40E), the bacterial cycle-inhibiting factor (Cif) family is able to inhibit CRL E3 activities, thereby interfering wit...

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Detalles Bibliográficos
Autores principales: Yu, Clinton, Mao, Haibin, Novitsky, Eric J., Tang, Xiaobo, Rychnovsky, Scott D., Zheng, Ning, Huang, Lan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4686759/
https://www.ncbi.nlm.nih.gov/pubmed/26632597
http://dx.doi.org/10.1038/ncomms10053

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4686759/
https://www.ncbi.nlm.nih.gov/pubmed/26632597
http://dx.doi.org/10.1038/ncomms10053

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