Elevated levels of TRF2 induce telomeric ultrafine anaphase bridges and rapid telomere deletions

The shelterin protein TRF2 is essential for chromosome-end protection. Depletion of TRF2 causes chromosome end-to-end fusions, initiating genomic instability that can be cancer promoting. Paradoxically, significant increased levels of TRF2 are observed in a subset of human cancers. Experimental over...

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Detalles Bibliográficos
Autores principales: Nera, Bernadette, Huang, Hui-Shun, Lai, Thao, Xu, Lifeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4686832/
https://www.ncbi.nlm.nih.gov/pubmed/26640040
http://dx.doi.org/10.1038/ncomms10132

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4686832/
https://www.ncbi.nlm.nih.gov/pubmed/26640040
http://dx.doi.org/10.1038/ncomms10132

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