Dual functions of Rap1 are crucial for T-cell homeostasis and prevention of spontaneous colitis

Rap1-GTP activates leukocyte function-associated antigen-1 (LFA-1) to induce arrest on the high endothelial venule (HEV). Here we show that Rap1-GDP restrains rolling behaviours of T cells on the peripheral lymph node addressin (PNAd), P-selectin and mucosal addressin cell adhesion molecule-1 (MadCA...

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Detalles Bibliográficos
Autores principales: Ishihara, Sayaka, Nishikimi, Akihiko, Umemoto, Eiji, Miyasaka, Masayuki, Saegusa, Makoto, Katagiri, Koko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4686857/
https://www.ncbi.nlm.nih.gov/pubmed/26634692
http://dx.doi.org/10.1038/ncomms9982

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4686857/
https://www.ncbi.nlm.nih.gov/pubmed/26634692
http://dx.doi.org/10.1038/ncomms9982

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